Combined toxic effects of T-2 toxin and propiconazole on the early life stages of zebrafish (Danio rerio)

نویسندگان

چکیده

Abstract Background Agricultural products are frequently co-contaminated by mycotoxins and pesticides. Most studies have only focused on the single toxicities of these chemicals, while their combined effects neglected. Therefore, we investigated toxic T-2 toxin (T-2) propiconazole (PRO) zebrafish ( Danio rerio ). Results Our data exhibited that had higher toxicity to embryonic fish (96-h LC 50 value 0.39 mg a.i. L −1 ) than PRO 17.16 The mixture showed an acute synergistic effect zebrafish. Meanwhile, indicators associated with oxidative stress (SOD, Mn-sod, cat displayed significant variations in most exposures mixtures (MTP) compared exposures. expressions apoptosis-related genes cas3 cas9 were also substantially elevated high-dose MTP exposure corresponding exposure. Besides, endocrine system-related TRβ , tsh crh cyp19a, vtg1 markedly varied present results suggested could cause enormous stress, cellular apoptosis, hypothalamic–pituitary–thyroid/hypothalamic–pituitary–gonadal (HPG/HPT) axis Conclusions provided new insights into development pollution standards for agricultural products. Taken together, impact be considered regulated as priorities.

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ژورنال

عنوان ژورنال: Environmental Sciences Europe

سال: 2023

ISSN: ['2190-4715', '2190-4707']

DOI: https://doi.org/10.1186/s12302-023-00714-7